Isolated CNS Relapse in Neuroblastoma

Abstract

We report three patients with primary extracerebral neuroblastoma and central nervous system (CNS) relapse. As the survival of children with metastatic neuroblastoma improves with recent advances in treatment, CNS involvement becomes more frequently detected. MR imaging of the brain and spine are strongly indicated in the follow-up of patients with increased risk of developing CNS disease.

Key words

Neuroblastoma - CNS relapse

References

• 1 DuBois S G, Kalika Y, Lukens J N. et al . Metastatic sites in stage IV and IVS neuroblastoma correlated with age, tumor biology, and survival.  J Pediatr Hematol Oncol. 1999;  21 181-189
• 2 Lohle P N, Wuzer H A, Seelen P J. et al . The pathogenesis of cysts accompanying intra-axial primary and metastatic tumors of the central nervous system.  J Neurooncol. 1998;  40 227-285
• 3 Matthay K K, Brisse H, Couanet D. et al . Central nervous system metastases in neuroblastoma: radiologic, clinical and biologic features in 23 patients.  Cancer. 2003;  98 155-165
• 4 Palasis S, Egelhoff J C, Morris J D. et al . Central nervous system relapse of treated stage IV neuroblastoma.  Pediatr Radiol. 1998;  28 990-994
• 5 Sener R N. CT of diffuse leptomeningeal metastasis from primary extracerebral neuroblastoma.  Pediatric Radiol. 1993;  23 402-403
• 6 Shaw D W, Weinberger E, Brewer D K. Leptomeningeal metastasis from primary extracerebral neuroblastoma: CT demonstration.  AJNR. 1990;  11 804